Acetyl salicylic acid solution and method of producing the same



Patented May 19, 1936- UNITED STATES ACETYL SALICYLIC ACID SOLUTION AND METHOD OF PRODUCING THE SALE Louis Hirschhorn, New York,-N. Y.

No Drawing. Application December 22, 1932,

Serial No. "648,442

9 Claims. The present invention embodies an improved acetyl salicylic acid solution and method of producing the same, the invention particularly embodying' an improved solution formed with a solvent or vehicle which facilitates the production of the solution and improves the physical char bodies a solution of acetyl salicylic acid in solvents or vehicles other than water, as suggested I 15 in applicant's copending application, above identified, as one form in which acetyl salicylic acid may be used. The solvent or vehicle described herein as particularly suited for use in connection with the present invention is glyce'ine and while other substances of similar nature may be used as the solvent or vehicle, the description of the inventionwwill be given with glycerine as the solvent.

An object of the invention accordingly is to pro- 25 vide an improved solution of acetyl salicylic acid without changing the chemical properties thereof or impairing its therapeutic value as a drug, the improved solution being stable and of a physical nature rendering the same more readily ad- 30 ministered.

A further object of the invention is to provide a solution of acetyl salicylic acid with another synergistic drug, the drugs' being held by an improved solvent or vehicle which renders the drugs 35 mutually soluble through a wider range of relative proportions than possible with the drugs alone or in solution with water. v

A further object of the invention is to provide an improved solution of acetyl salicylic acid with 40 a vehicle which improves the taste and smell of the drugs and renders the same more readily administered at the same time preventing hydrolysis of either or any of the drugs upon long standing.

and in this specification to those central nervous 50 system depressants which have a selective effect on the pain and heat regulating centers of the brain. The function andyrop rties of the resulting solution are similar to those described in applicant's copending application above referred ,65 to and, briefly statedare as follows. Byintroducing the acetyl salicylic acid into the system in solution, its potency and eflectiveness are greatly increased, being rapidly, assimilated or absorbed without decomposition and greatly increasing the effectiveness thereof. Moreover, being in 5 liquid form, the drug may be administered more effectively and in a more agreeable fashion than possible with the drug in solid form.

Where the acetyl salicylic acid solution is formed with water, hydrolysis of one or more of the drugs may take place in time and it has been found that, upon standing for some time, such solutions frequently have objectionable taste and odor even though the therapeutic action thereof is not appreciably impaired. Such hydrolysis produces acetic acid and salicylic acid which impart the objectionable taste and odor above referred to.

'In accordance with the present invention and in carrying out the same, acetyl salicylic acid is put into solution by mixing the same with one of the drugs of the analgesic and antipyretic group and heating gently. At the same time, glycerine is added to the solution and it has been found that a satisfactory mixture may be formed. by using ingredients in the proportion of one gram of acetyl salicylic acid, one gramv of amidopyrine or antipyrine and c.c. of glycerine.

The above substances when placed in the glycerine and heated will go into complete solution, 30 stirring assisting suchaction. Varying proportions of acetyl salicylic acid and antipyrine or amidopyrine and glycerine may be used as will be readily apparent. Instead of using antipyrine or amidopyrine, other substances in this group of analgesic antipyretic drugs such as acetanilid, phenacitine, melubrine, quinine, compounds of the phenyl cinchoninic acid series and the like my be used as set forth in the above identified copending application. 40

Since no water is used in the foregoing solution no hydrolysis of the ingredients takes place and it has been found that the drugs are actually soluble through a wider range of relative proportions in the presence of glycerine than with water. For example, it has been found thatacetyl salicylic acid and pyramidon will dissolve in glycerine in the proportions 1-1 whereas this of these compounds. The solution may. be made so that each teaspoon contains the desired quantity oi. each drug. An advantage of this solution is that the glycerine acts as'a preservative and antiseptic in this concentrated state. A further advantage of this solution is that it dissolves in water in all proportions. This property permits of the ready formation of a fresh, agreeably flavored water solution of these drugs when needed by the patient.

The word "solution has been used in the speciflcation as well as in the appended claims in its broader sense and includes the mutual solution oi! two solids in each other as well as dlssolution'in a fluid solvent.

I claim as my invention:

1. A mutual solution of acetyl salicylic acid and a drug of the analgesic and antipyretic group in glycerlne.

2. A mutual solution of acetyl salicylic acid and a drug of the pyrazolon group in glycerine.

3. A'mutual solution of acetyl" salicylic acid and amidopyrine in glycerine.

4. A mutual solution of acetyl salicylic acid and antlpyrine in glycerine.

5. A mutual solution 01' acetyl salicylic acid and melubrine in glycerine.

6. The method or preparing a potentlated solution of acetyl salicylic acid which comprises mixing solid acetyl salicylic acid with another solid analgesic and antipyretic drug and with glycerine and applying heat sufllcient to cause mutual solution only.

7. The method of preparing a potentlated solution of acetyl salicylic acid'which comprises mixing solid acetyl salicylic acid with solid antipyrine and with glycerine and applying heat sufllcient to cause mutual solution only.

8. The method otpreparing a potentlated solution of acetyl salicylic acid which comprises mixing solid acetyl salicylic acid with solid ami- 

